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Gap junction gamma-1 protein

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A protein involved in cell-cell contacts that provides intercellular communications in various physiological processes including neuronal excitability, epithelial electrolyte transport and cardiac and smooth muscle contraction.


Gap junction gamma-1 protein gene is mapped on chromosome 17q21.31 containing 5 exons span at about 2.2kb belong to the connexin family that forms gap junction channel that gives path for the diffusion of small molecular weight materials from cell to cell.

Gap junction gamma-1 protein expressed abundantly in granulosa cells from preovulatory follicles and it is prominent in the trabeculated layer during embryonic development with lower concentration in the compact layer.

Gap junction gamma-1 protein gene mutation is implicated in some diseases like skin disorders, sensorineural deafness, peripheral neuropathy and cardiovascular disease as well as the most common cystic fibrosis.

Gene name: GJC1

Protein name: Gap junction gamma-1 protein





Gap junction alpha-7 protein

gap junction protein, alpha 7, 45kDa

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