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Fusobacterium nucleatum

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A gram-negative fusiform small spindle-shaped rod bacterium involved in preterm pregnancy and periodontal disease in human.


Fusobacterium nucleatum contains an outer membrane with periplasmic space made of the peptidoglycan layers between inner and outer cytoplasmic membranes wherein the inner membrane made of a symmetrical phospholipids bilayer with proteins and phospholipids while the outer membrane is an asymmetric membrane composed of phospholipids, lipoproteins, lipopolysaccharide and proteins.

Fusobacterium nucleatum has been isolated from amniotic fluid, chorioamnionic membranes and placenta in premature delivery of women. It is also implicated in dental plaque of humans associated with gum disease due to its abundance and capability to coaggregate with other species in the oral cavity and much linked with periodontitis along with intensive human infections of the head and neck, liver, lung, chest and abdomen.

Fusobacterium nucleatum has a very high chance to be pathogenic due to its extreme frequency in periodontal lesions and due to its adherence ability it can be associated with viruses attaching the host cell tissue as an invasion as well as adjust the immune response of the host and it is known as common clinical infection to other body sites.

Scientific classification:

 Kingdom: Bacteria
 Phylum: Fusobacteria
 Order: Fusobacteriales
 Family: Fusobacteriaceae
 Genus: Fusobacterium
 Species: Fusobacterium nucleatum

See also:

• Bacteria

• Periodontitis