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Fusion proteins bcr-abl

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Fusion proteins, bcr-abl

translation products of a fusion mrna derived from the breakpoint cluster region (bcr) gene and a cellular abl (c-abl) gene translocated to chromosome 22. The p210(bcr-abl) fusion protein is found in patients with chronic myelogenous leukaemia. The p190(bcr-abl) fusion protein is found in patients with acute lymphocytic leukaemia. The activation of human c-abl by chromosomal translocation is essentially the same as the activation of murine c-abl by viral translocation in abelson murine leukaemia virus.