Focal Adhesion Kinase
Focal Adhesion Kinase is found at the cell membrane where cytoskeleton interacts with proteins in the extracellular matrix. It is a tyrosine kinase which is enlisted at early stage of focal adhesion that intercede several downstream responses, such activity is activated by the non-receptor tyrosine kinase which is recruited at the binding site generated by autophosphorylation.
Focal Adhesion Kinase has been shown to blocked breast cancer cell where it became less metastatic due to less mobility and plays an important early step of cell migration. It is also draw out intracellular signal transduction pathway that encourage the turnover of cell contact with the extracellular matrix upholding cell migration and regulation of tumor suppressor p53.
Focal Adhesion Kinase is a protein of 125kD engaged as contributor in focal adhesion dynamics between cells motility and survival. It is highly conserved and originally identified as a substrate for the oncogene protein tyrosine kinase, thereby implicated in diverse cellular processes and typically located at structures of focal adhesion linked with extracellular matrix constituents to the cytoplasmic cytoskeleton.
Gene name: PTK2
Protein name: Focal adhesion kinase 1