Flavin-containing monooxygenase 4
Flavin-containing monooxygenase 4 gene is mapped on chromosome 1h2.1 that contains 14 exons which involved in the oxidative metabolism of variety of xenobiotics like drugs and pesticides. It renovates many xenobiotics into more polar substance as a prelude to excretion and catalyzes the reactive metabolites proficient for binding to cellular macromolecules.
Flavin-containing monooxygenase 4 is present in low profusion in some fetal and adult tissues and the corresponding gene appears to be expressed constitutively. It is about 56% identical to FMO3 encoded by a single gene. Its transcripts with all those encoding all known FMO isoforms revealed a coding region of 60 to 75 nucleotides longer than the transcripts of other isoforms due to the shift in the stop codon at the 3’-end of the consensus positions.
Flavin-containing monooxygenase 4 is associated with plasma cell neoplasm andtrimethylaminuria. It includes putative FAD- and NADP+ pyrophosphate binding sites in which C-terminal hydrophobic segment is believed to anchor the monooxygenase to the microsomal membrane.
Gene name: FMO4
Protein name: Dimethylaniline monooxygenase [N-oxide-forming] 4