(Science: disease) An acute viral infection (human parvovirus) in children that manifests with a fever and a unique facial rash (slapped cheek appearance). After 1-2 days the rash will often spread to the extremities and trunk. The illness is nonserious and self-limiting. Environmental factors such as sunlight, hot baths and emotional factors can cause the rash to recur. Referred to as fifth disease or erythema infectiosum.