Fibroblast growth factor 4
Fibroblast growth factor 4 gene mapped on chromosome 11q13.3 belong to the fibroblast growth factor family that possess wide mitogenic and cell survival in several biological processes such as cell growth, morphogenesis, embryonic development, tumor growth, tissue repair andinvasion.
Fibroblast growth factor 4 comprises an extracellular domain, an intracellular domain and a transmembrane domain with 18 different alternatively splicing isoforms where it possesses 802 amino acids. It is expressed in tissue specific manner that exhibits unique affinity for certain FGF ligands which is essential in embryogenesis as well as in adult life where it is particularly expressed in tissues including adrenal cortex, cervix, cornea, bile duct, corneal epithelial cell, hepatocytes, intestine, heart, islet of Langerhans, lamina propria, kidney, liver and lung.
Fibroblast growth factor 4 gene mutation is implicated in gallbladder squamous cell carcinoma, prostate cancer, melanoma, hepatocellular carcinoma, gastric cancer, colorectal cancer, pancreatic cancer and mammary carcinoma cell line.
Gene name: FGF4
Protein name: Fibroblast growth factor 4