Fascin gene encloses 5 exons and spans of 7 kb that has 54-58 kD monomeric actin filament packing protein which is originally isolated from sea urchin egg. It is spaced at 11 nanometer intervals along thefilament where a bundle in cross section is seen to be hexagonally packed and the longitudinal spacing links at alternating 4 and 5 actins.
Fascin is also present in fibroblast growth factors, ricin B-like lectins,agglutinin, and interleukin-1. It is calcium insensitive that binds beta-catenin which localizes at the edge of epithelial and endothelial cells. It also regulates cytoskeletal structures for the preservation of cell adhesion, synchronizing motility and invasion through signaling pathways related with protrusive actin dynamics. Moreover, fascin is a motility-promoting wherein extracellular stimuli induced by cell adhesion to thrombospondins,fibronectin and laminin to trigger the formation of fascin containing actin microspikes.
Fascin irregularity leads to colon cancer, breast cancer, prostate cancer, gallbladder cancer and esophageal squamous cell carcinoma. Furthermore, fascin staining is higher in more advanced stage tumors and correlated with increased probability of metastasis to lymph nodes. Tumor cell that has been noted with high fascin content inversely low expression of Ki-67 a marker for proliferation.
Gene name: FSCN1
Protein name: Fascin