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An abbreviation for fluorescence ‘’in situ’’ hybridization, a cytogenetic technique using fluorescent probe to detect and localize the presence of specific DNA sequence on chromosomes.


FISH can be used to find specific features in DNA for use in genetic counseling, medicine, and species identification. FISH can also be used to detect and localize specific mRNAs within tissue samples.

Word origin: from the abbreviation of fluorescence in situ hybridization.