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Elongation factor

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Elongation factor

(Science: biochemistry) peptidyltransferase components of ribosomes that catalyse formation of the acyl bond between the incoming amino acid residue and the peptide chain.

there are three classes of elongation factor: EF1_ (EF tu in prokaryotes) binds gtp and aminoacyl trna, delivering it to the a site of ribosomes. EF 1_ (EF Ts) helps in regeneration of gtp EF 1_. EF 2 (EF G) binds gtp and peptidyl trna and translocates it from the a site to the P site. Diptheria toxin inhibits protein synthesis in eukaryotes by adding an adp ribosyl group to a modified histidine residue (dipthamide) in elongation factor II.