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Egf like domain

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Egf like domain

region of 30-40 amino acids containing 6 cysteines found originally in egf and also in a range of proteins involved in cell signalling.

Examples: tgf _, amphiregulin, urokinase, tissue plasminogen activator, complement C6 C9, fibronectin, laminin (each subunit at least 13 times), nidogen, selectins. It is also found in the drosophila gene products: notch (36 times) delta, slit, Crumbs, Serrate.