Dual-specificity phosphatase 3
Dual-specificity phosphatase 3 genes is mapped on chromosome 17q21.31 that contains C-terminal catalytic domain yet lack N-terminal domain found in mitogen-activated protein kinase. It also makes up a large heterogeneous type I cysteine-based protein tyrosine phosphatase superfamily. It has been initially designated as VHR due to its close similarity to VH1 gene in vaccinia virus.
Dual-specificity phosphatase 3 activity is due in part of catalytic activation after tight binding of its amino-terminal to the target MAP kinase where it is induced strongly by various growth factors and cellular stress providing complicated transcriptional methods for the selectedMAP kinase activities as well as negative regulators associated with cellular proliferation and differentiation.
Dual-specificity phosphatase 3 has been implicated as major modulators of critical signaling pathways and shows distinct substrates specifications for various MAP kinases, subcellular localization, tissue distribution and diverse forms of inducibility by extracellular stimuli. Its gene mapped in a region that contains BRCA1 locus that reveals susceptibility to breast and ovarian cancer.
Gene name: DUSP3
Protein name: Dual specificity protein phosphatase 3