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From Biology-Online Dictionary
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1. To deprive of cheerful spirits; to depress the spirits of; to dishearten; to discourage. Not dispirited with my afflictions. (Dryden) He has dispirited himself by a debauch. (Collier)

2. To distill or infuse the spirit of. This makes a man master of his learning, and dispirits the book into the scholar. (Fuller)

Synonym: to dishearten, discourage, deject, damp, depress, cast down, intimidate, daunt, cow.

Origin: Pref. Dis- _ spirit.