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Disintegrins

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Disintegrins

(Science: chemical) a family of polypeptides purified from snake venoms, which contain the arginine-glycine-aspartic acid (rgd) sequence. The rgd tripeptide binds to integrin receptors and thus competitively inhibits normal integrin-ligand interactions. Disintegrins thus block adhesive functions and act as platelet aggregation inhibitors.

Pharmacological action: platelet aggregation inhibitors.