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Dermatan sulphate

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Dermatan sulphate

Glycosaminoglycan (15-40 kD) typical of extracellular matrix of skin, blood vessels and heart. Repeating units of D glucuronic acid N acetyl D galactosamine or L iduronic acid N acetyl D galactosamine with 1-2 sulphates per unit. Broken down by L iduronidase, but accumulates intra lysosomally in hurler syndrome and hunter syndrome.