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From Biology-Online Dictionary
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1. Detraction; depreciation. To stubborn critics, apt, without a theme, For depravation. (Shak)

2. The act of depraving, or making anything bad; the act of corrupting.

3. The state of being depraved or degenerated; degeneracy; depravity. The depravation of his moral character destroyed his judgment. (Sir g. C. Lewis)

4. (Science: medicine) change for the worse; deterioration; morbid perversion.

Synonym: depravity, corruption. See depravity.

Origin: L. Depravitio, from depravare: cf. F. Depravation. See deprave.