Confused and have questions? We’ve got answers. With Chegg Study, you can get step-by-step solutions to your questions from an expert in the field. If you rather get 1:1 study help, try 30 minutes of free online tutoring with Chegg Tutors.

Debrisoquin

From Biology-Online Dictionary
Jump to: navigation, search

Debrisoquin

(Science: chemical) An adrenergic neuron-blocking drug similar in effects to guanethidine. It is also noteworthy in being a substrate for a polymorphic cytochrome p-450 enzyme. Persons with certain isoforms of this enzyme are unable to properly metabolise this and many other clinically important drugs. They are commonly referred to as having a debrisoquin 4-hydroxylase polymorphism.

Pharmacological action: adrenergic agents, antihypertensive agents, sympatholytics.

chemical name: 2(1H)-Isoquinolinecarboximidamide, 3,4-dihydro-