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Cyclooxygenase 1

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It is the key enzymes in prostaglandin biosynthesis necessary in promoting cell proliferation of normal and neoplastically transformed cell for the healthy kidney and stomach lining.


Cyclooxygenase 1 is also identified as prostaglandin-endoperoxide synthase (PTGS1) which has gene of 40kb long with 11 protein coding exons and has 599 amino acid residues with molecular mass of approximately 68kD that has been mapped to chromosome 9.

Cyclooxygenase 1 is repressed by non-steroidal anti-inflammatory drugs like aspirin that act to reduce platelets aggregation in which inhibition of COX1 is adequate evidence why aspirin is efficient in reducing cardiac events. Prostaglandin synthase 1 gene disturbance may reduce arachidonic acid-induced inflammation and indomethacin-induced gastric ulceration.

Cyclooxygenase 1 molecular functions involved peroxidase activity, prostaglandin-endoperoxide synthase activity, dioxygenase action, heme binding and metal ion binding where it present in almost all cell types at stable point. The prostaglandin produced by COX1 confer safeguard on the epithelial cells as well as promotes crypt stem cell survival and proliferation.

Acronym: COX1

Gene name: PTGS1

Protein name: Prostaglandin G/H synthase 1





PGH synthase 1


Prostaglandin H2 synthase 1

Prostaglandin-endoperoxide synthase 1

See also: