Cyclin D2 belongs to the extremely preserved family that distinguished by spectacular periodicity in protein abundance through cell cycle. It is mapped in chromosome 12p13 that reveals expression in human ovary which signifies a novel marker of ovarian function associated with aging process that provides significant role in ovarian granulose and germ cell proliferation, thus high amount of this gene observed in ovarian and testicular tumors
Cyclin D2 serves as regulators of CDK kinase that exhibit distinct expression and degradation patterns that convey to the sequential dexterity ofmitosis. Alteration of thisgene is linked with megalencephaly-polymicrogyria-polydactyly-hydrocephalus syndrome 3 (MPPH3).
Cyclin D2 is the main integrators of several mitogenic and anti-mitogenic signals that act as a substrate for SMAD3 in cell cycle repressing its transcriptional activity. It has a molecular weight of 33,067 Da that are normally found in nuclear membrane, chromatin, nucleus, nucleolus and cytosol.
Gene name: CCND2
Protein name: G1/S-specific cyclin-D2