Cyclin-dependent kinase inhibitor 1C
Cyclin-dependent kinase inhibitor 1C gene in mapped onchromosome 11p15.5 that contains 3 exons and 316 amino acids consisting of 3 structurally distinct domains which encodes in tight binding strong inhibitor of several G1 cyclin complexes. It is high in adrenal tissue than in brain and muscle during early development.
Cyclin-dependent kinase inhibitor 1C gene is generally inherited one copy from both parents but it is fully turned on and most active when it is inherited from the mother in contrast to the father that only shows a less active in most tissues and this phenomenon is due to genomic imprinting.
Cyclin-dependent kinase inhibitor 1C gene mutations leads to uncontrolled cellular proliferation linked to the increased risked of tumor formation in childhood. It is associated in Beckwith-Wiedemann syndrome, a condition that causes overgrowth increasing the risk of tumors that affects many parts of the body resulted from the changes in the process of methylation that affects to certain segments of DNA. It also linked with several types of childhood tumors such as Wilms tumor, adrenocortical carcinoma and rhabdomyosarcoma.
Gene name: CDKN1C
Protein name: Cyclin-dependent kinase inhibitor 1C
• G cyclin