Cyclin-dependent kinase 6
Cyclin-dependent kinase 6 gene is mapped on chromosome 7q21 containing 11 exons with multiple transcript variants that promote production of newborn neurons by modulating G1 length where it accumulates in squamous cell carcinomas, beta cell of Islets of Langerhans, proliferating hematopoietic cells and neuroblastomas.
Cyclin-dependent kinase 6 interacts with D-type G1 cyclins during interphase to form RB1 kinase and controls the entrance into the cell cycle. It is vital for the proliferation of the dentate gyrus of the hippocampus and subventricular zone as well as needed during the thymocyte development. It upholds in astrocytes, changes in the actin cytoskeleton, gene expression patterns and boost movement during cell differentiation.
Cyclin-dependent kinase 6 misregulation can lead to unscheduled proliferation, genomic instability and chromosomal unsteadiness. It has been revealed in some types of cancer such as in leukemia, lymphoma and melanoma and currently studied as a potential targets for antineoplastic therapy.
Gene name: CDK6
Protein name: Cyclin-dependent kinase 6