Cullin 2 genes mapped on chromosome 10p11.2-p11.1 a region that shows loss of heterozygosity in various forms of cancers. It mediates the ubiquitination of target proteins which dole out as a rigid scaffold in the complex and contributes the catalysis through positioning of the substrate and the ubiquitin-conjugating enzymes and affects the ubiquitination of RNA-binding protein that regulate the stability of hypoxia-inducible mRNAs.
Cullin 2 play a vital role in targeting proteins for ubiquitin-mediated destructions through the regulation of different processes such asglucose sensing, DNA replication and circadian rhythm. It is required for the G1 to S phase transition andmitotic chromosome condensation and significant in ubiquitin-ligase complex with von Hippel-Lindau tumor suppressor protein.
Cullin 2 mutations is associated in familial clear cell renal carcinoma and serves as a tumor markers. It targets gene products levels including levels of vascular endothelial growth factor and glucose transporter. It is required for degradation of a class of RNA-binding germline proteins in somatic cells of the early blastomere.
Gene name: CUL2
Protein name: Cullin-2