Corticosteroid-binding globulin gene is mapped on chromosome 14q32.13 span at about 60kDa with 9 alpha-helices and 3 beta-sheets which binds in a largely hydrophobic pocket that act to buffer the concentration of free cortisol in the blood to maintain it constant despite its strong secretion movement. It is associated in stress response by discharging cortisol in the inflammatory sites upon cleaving neutrophil elastase.
Corticosteroid-binding globulin it is chiefly expressed in plasma as well as in some glycocorticoid responsive cells where it is synthesized in the liver. It is localized in the chromosomal region holding many closely related serine protease inhibitors evolved from copying of events.
Corticosteroid-binding globulin deficiency is associated with frequent extreme fatigue after physical exertion in which individual manifest this condition has low blood pressure, fatty liver and chronic pain particularly in muscles. Mutation of genes characterized by rare hereditary disorder through corticosteroid binding capacity either low or high concentration in plasma associated to hypotension or hypertension and muscle fatigue.
Gene name: SERPINA6
Protein name: Corticosteroid-binding globulin