A blood test that measures the speed of blood coagulation at different steps of the coagulation pathway
The coagulation profile is a screening test performed in order to determine the speed of blood coagulation at different steps of coagulation pathway and therefore can be used to identify the reason behind an abnormal bleeding, i.e. at which phase of coagulation pathway is affected. However, it does not identify all causes of bleeding abnormalities.
The coagulation profile typically includes the following: 1, 2
- Prothrombin time (PT)
- Activated Partial Thromboplastin Time (APTT)
- Fibrinogen Degradation Product (FDP)
- Platelet count
- D-dimer (sometimes included)
The test is done by collecting a few milliliters of blood from a vein into a blood sample tube.2 It is usually performed prior to procedures that involve bleeding such as surgeries. The result is assessed in order to determine which part of the coagulation pathway is affected. For instance, APTT may be increased by therapy involving intravenous heparin, hemophilia, or DIC.2
1 Fischbach, F T and Dunning, M B . A manual of laboratory and diagnostic tests, Lippincott Williams and Wilkins, 2008.
2Coagulation Profile Test. 2015. URL: http://healthengine.com.au/info/Coagulation_Profile_Test