(Science: disease) An acute, subacute or chronic infection by the fungal organism, cryptococcus neoformans. Infection generally causes a pulmonary infection but may also disseminate to the meninges. The pulmonary form is generally mild and transient (often unrecognised). With dissemination lesions may occur in the skeletal, cutaneus and visceral tissues. The most commonly recognised dissemination is to the central nervous system (meningitis).