Brockmann body

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(ichthyology) An aggregation of islet tissues in some teleost fish


The large aggregation of islet tissues found in certain teleost fish is called Brockmann body. It is regarded as the endocrine organ since it is involved in the production of insulin. Brockmann body is comprised of islet tissues. The islet tissues in turn are made up of endocrine cells. The endocrine cells are responsible for the synthesis of insulin.1 It is also producing other hormones such as glucagon and somatostatin. The hormones that the Brockmann body produces indicate that the Brockmann body is akin to the islets of Langerhans of the pancreas, which are largely responsible for the production of hormones that regulate blood glucose level. The presence of high glucose level incites the Brockmann body to release insulin. The somatostatin is later on produced to inhibit insulin production by the endocrine cells.

The Brockmann body draws medical interest lately due to its potential use in the management of type 1 diabetes mellitus. Insulin can be extracted easily from the endocrine cells of Brockmann body. Furthermore, these tissues are capable of regenerating following harvest.3

The name is derived from Heinrich Brochmann, a German physician, who first described it in 1848.2

See also:

1 Pisharath, H. (2009). Characterizing Endocrine Progenitors in Developing and Regenerating Zebrafish Pancreas. ProQuest. p. 7.
2 Suehiro, M. (1992). "Historical review of insulin and its preparations in pharmacopoeia (3). Fish insulins".Yakushigaku Zasshi (in Japanese) 27 (1): 32–39.
3 Intine, R. V., Olsen, A. S., & Sarras, M. P. (2013). "A zebrafish model of diabetes mellitus and metabolic memory". Journal of Visualized Experiments 72: e50232.