Aurora kinase B
Aurora kinase B gene is mapped on chromosome 17p13.1 that localizes in prophase, prometaphase, metaphase and mitotic spindle in anaphase that significantly limits its mobility to the cell equatorial cell cortex transported by astral microtubules.
Aurora kinase B phosphorylates the chromosomal passenger complex subunits survivin, borealin and INCENP in which this complex has essential functions at thecentromere to make certain the correct alignment and segregation of chromosome that is needed for chromatin induced microtubule stabilization and spindle assembly. It is also implicated in the centromeric function and mitosis as key component of the cytokinesis checkpoint to delay abscission preventing premature resolution of intercellular chromosome bridges and DNA damage.
Aurora kinase B associates with tubules during chromosomemovement and segregation that is located near kinetochore known as K-fibers that inhibits the depolymerizing activity of mitotic centromere associated kinesin by phosphorylating MCAK on Ser92.
Gene name: AURKB
Protein name: Aurora kinase B
• Aurora 1