Aurora kinase A
Aurora kinase A gene is mapped on chromosome 20q13.2-q13.3 and 1q41-q42 that is encoded in cell cycle regulated kinase found at the centrosome in interphase cells and at the spindle poles inmitosis. It plays a vital role in tumor progression and development. It also essentials for the proper separation of the centrosome after mitotic spindle formation.
Aurora kinase A is an important regulators in mitosis over-expressed in different solid tumors that has been proposed as a drugable target in pancreatic cancer wherein it exhibits a unique conformation around the activation loop region boosted the development of inhibitor aurora kinases which has the capacity as a novel anti-oncogenic agents.
Aurora kinase A dysregulation has been linked with high occurrence incancers in which 94% of these enzymes found in tissue growth of breast cancer compared to the surrounding normal tissue that has a normal level of aurora kinase A. Moreover, these enzymes is needed for the completion of cytokinesis but when hindered during mitosis it will unable to divide into two separate cells resulting to aneuploidy or more chromosome than normal leading to many cancerous tumors.
Gene name: AURKA
Protein name: Aurora kinase A