Arrestin beta-2 is predominantly localized in neuronal tissues and spleen which is also exhibited 78% amino acid identity with arrestin beta-1 that consist a primary structure delineated to the family of proteins that regulate receptor coupling to G proteins. It also acts as a gibbet protein which transports the spatial distribution and movement of MAPK element under the control of G protein-coupled receptor.
Arrestin beta-2 partakes in agonist-mediated desensitization of G-protein receptors and definite dampening of cellular responses to stimuli like neurotransmitters and hormones which are also inhibit beta-adrenergic receptor. It is an adaptor protein that terminates G-protein activation implicated in the modulation of the inflammatory response.
Arrestin beta-2 is associated in apoptotic cell death and retinal degeneration of the endocytic mechanism. Study reveals that arristen beta-2 binds to the single beta-glycan which is triggered by phosphorylation of the receptor on its cytoplasmic domain mediated by the type II TGF-beta receptor, a kinase not a G protein-coupled receptor that lead to internalization of both receptors and downregulation of TGF-beta signaling. Moreover, the regulatory action of these proteins is wider extending to the TGF-beta receptor family.
Gene name: ARRB2
Protein name: Beta-arrestin-2