Arginine vasopressin receptor 1A
Arginine vasopressin receptor 1A gene is mapped on chromosome 12q14.2 containing 3 exons belongs to the G-protein coupled receptors subfamily. It is involved in the control of body fluid, blood pressure, blood volume and vascular tone.
Arginine vasopressin receptor 1A is mostly expressed in the brain, kidney, liver and vasculature mediated by G-protein that activates a phospholipase C which in turn excites phosphatidylinositol turnover to enhance intracellular calcium ion.
Arginine vasopressin receptor 1A gene mutation is associated in typical autism wherein allele tends to show less structuring and support throughout the interaction associated with social behaviors including attachment and affiliation where mutation occurs at the repetitive sequence in the 5’ flanking region.
Gene name: AVPR1A
Protein name: Vasopressin V1a receptor