Arginase type II
Arginase type II gene is mapped onchromosome 14q24.1-q24.3 with 355 amino acids span at about 1.5kb present in several tissues such as brain, prostate and kidney. It is implicated in the regulation of ornithine concentration in the cell that is involved in the biosynthetic functions as opposed to the metabolic cycle of urea.
Arginase type II is necessary in the regulation of nitric oxide biosynthesis by modulating local arginine level like for example in pulmonary arterial hypertension has a higher expression of arginase II and generates lower nitric oxide, thus substrate availability affects nitric oxide activity and vasodilation implicating arginase II and modification of arginine metabolic pathways is essential in pathophysiology of pulmonary arterial hypertension.
Arginase type II is associated as a potential target for the treatment of female and male sexual arousal disorders in which in diabetic corpus cavernosum shows an increased expression of these enzymes leading to erectile dysfunction. It also linked in carcinoma follicular tumor.
Gene name: ARG2
Protein name: Arginase-2, mitochondrial