A water channel that act as an anion selective channel localized exclusively at intracellular membranes of renal epithelia involved in glomerular filtration, acid-base metabolism and tubular endocytosis.
Aquaporin 6 gene is mapped onchromosome 12q13 span at about 75kDa that inhabits abundantly in vesicular fractions located at intracellular membrane vesicles. It is a gated channel by single-channel patch recording with oocyte membranes that contains most of the conserved amino acid residues including the NPA motifs.
Aquaporin 6 is present in membrane vesicles within podocytes cell bodies and foot processes at the glomeruli whereas in proximal tubules it is present within the subapical compartment of segment 2 and segment 3 cells but not detected in the brush border membranes. It is found in the kidney and gastrointestinal tract as well as localized in the inner ear of mammals.
Aquaporin 6 is a pH-regulated anion channel that has been bind to calmodulin in a calcium-dependent manner providing a significant physiological role in kidney and is critical for its unique anion limited water permeability, thus my lead to major differences in biophysical function.
Gene name: AQP6
Protein name: Aquaporin-6