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Apolipoproteins e

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Apolipoproteins e

prominent protein constituents of plasma vldl, chylomicrons, and a subfraction of hdl as well as of remnant lipoproteins which are derived from the lipoprotein lipase-mediated intravascular catabolism of triglyceride-rich lipoproteins. Apolipoproteins e are recognised by the ldl receptor and apo e receptor. Any defect in the apo e metabolism leads to increased plasma apo e levels. A strong association has been found between high levels of apo e and type III hyperlipoproteinaemia.