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Annexin I

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Definition

noun

A glucocorticoid of calcium and phospholipid binding proteins that plays an important role as anti-inflammatory mediators.

Supplement

Annexin I is also known as lipocortin I (Lipo1) that belongs to the family of annexins which are preferentially situated on the cytosolic face of the plasma membrane that serves as the mediator in biosynthesis of prostaglandin and leukotrienes. It is also an endogenous anti-inflammatory mediator that activates in the body to ensure the transitory shape of the inflammatory reaction.

Annexin 1 are largely expressed by neutrophils, eosinophils, monocytes, and a little amount in lymphocytes in humans. There are two types oflipocortins (I and II) that signifies the distinct short amino terminal sequence from the core structure which shows rigid functions reliant on its phosphorylation state. It also upholds membrane fusion and involved in exocytosis that appears to bind from two to four calcium ions with highaffinity.

In mouse, annexin 1 gene spans about 17 kb with 13 exons and is mapped to chromosomes 9q11-q22 and it has an evident relative molecular mass of 40 kDa, with phospholipase A2 inhibitory activity.

Gene name: ANXA1

Protein name: Annexin A1

Synonyms:

Calpactin II

Calpactin-2

Lipocortin I

Phospholipase A2 inhibitory protein

p35

Chromobindin-9

See also:

Annexin

macrophages