Angiotensinogen is a member of serpin family even though it is not identified to inhibit other enzymes unlike most serpins. It is also recognized as renin substrate and the gene is mapped at chromosome 1q42.2 that contains 5 exons which consists of 450 amino acids and usually polar.
Angiotensinogen is a protein and hormone originator that implicated in the renin-angiosten-aldosterone system which causes in high blood pressure. It is generated in theliver and secreted into the bloodstream that acts as the substrate for the enzyme renin. It also serves as a potential indicator of hypertension and found to have a strong links among hypertension and ethnicity.
Angiotensinogen stimulates thirsty brain through increasing blood pressure by constricting blood vessels and signal the release of vasopressin which increases retention of water in the kidney and aldosterone that increase salt retention, both increases the fluid volume in the bloodstream, thus raising the blood pressure.
Angiotensinogen is the precursor expressed in the liver and the resulting product is angiotensin I which is then cleaved by angiotensin converting enzyme to make physiologically active enzymeangiotensin II that drawn in upholding blood pressure and pathogenesis of crucial hypertension and preeclampsia. A mutation in this gene is related to hypertension and causes renal tubular dysgenesis, a severe disorder of renal tubular development.
Gene name: AGT
Protein name: Angiotensinogen