Angiotensin-converting enzyme inhibitor

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Angiotensin-converting enzyme inhibitor

(Science: pharmacology) a class of drugs used in the treatment of hypertension and heart failure.

They exert their haemodynamic effect mainly by inhibiting the renin-angiotensin system and produce a reduction of peripheral arterial resistance. They also modulate sympathetic nervous system activity and increase prostaglandin synthesis. They cause mainly vasodilation and mild natriuresis without affecting heart rate and contractility.