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Angiopoietin 1

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Definition

noun

A protein that is vital in vascular development particularly in the endothelium by regulating tyrosine phosphorylation of the membranereceptor Tie 2.

Supplement

Angiopoietin1 has been identified independently in cDNA encoding as KIAA0003 and mapped to chromosome 8q22.3-q23 in humans. It requires to bind in Tie 2 to cause phosphorylation of the receptor however angiopoietin 2 hindered this binding thus, blocks receptor phosphorylation that happen in the sites of vascular remodeling,dorsal aorta, major aortic branches, ovary, placenta anduterus.

Angiopoietin1 is important for vessel survival, adhesion, migration andmaturation. On the other hand angiopoietin 2 encourages cell death and disrupts vascularization and acts as natural antagonist of angiopoietin 1 yet when it is combined with vascular endothelial growth factors (VEGF) will encourage neo-vascularization.

Angiopoietin1 encoded 498 amino acids polypeptide with a molecular weight of 57 kDa that able to form dimers, trimers and tetramers and in some cases has the ability to form higher order multimers whereas angiopoietin 2 encoded 496 amino acids polypeptide. The protein programmed by this gene is a secreted glycoprotein that makes active thereceptor by inducing itstyrosine phosphorylation and plays vital role to mediate reciprocal interactions flanked by endothelium and surrounding matrix to inhibit permeability.

Acronym: Ang1; ANGPT1

See also:

Angiopoietin

Vascular Endothelial Growth Factor

Human proteins