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Androstenediol

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Definition

noun, plural: androstenediols

A steroid hormone, with a chemical formula of C19H30O2, and a precursor of androgen and estrogen




Supplement

Androgen is one of the major classes of sex steroids (or sex hormones) of vertebrates, including humans. Androgens include androstenediol (A5), androstenedione (A4), dehydroepiandrosterone (DHEA), dihydrotestosterone (DHT), androsterone, and testosterone. Androstenediol (A5) is an unsaturated, weak endogenous androgen. It contains two alcohol groups. Three isomers of androstenediol occur. A5 is closely related to androstenedione (A4) in terms of structure. A5, though, is less androgenic than A4. A5 is a derivative of androstane and an intermediate in testosterone biosynthesis (from dehydroepiandrosterone). It also has estrogenic activity just at other androgens, such as DHEA and A4.

A5 may also be synthesized synthetically. It is one of the anabolic steroids. It is administered orally. It has been found to have an effect in the immune system. It can stimulate the production of white blood cells and platelets. As such, it has been studied for use as a radiation countermeasure, and is being investigated for the treatment of acute radiation syndrome.1



Chemical formula:

  • C19H30O2

Synonym(s):

  • hermaphrodiol
  • 5-androstenediol (A5)
  • androst-5-ene-3β,17β-diol

See also:


Reference(s):
1 Whitnall, M. H., Elliott, T. B., Harding, R. A., Inal, C. E., Landauer, M. R., Wilhelmsen, C. L., McKinney, L., Miner, V. L., Jackson, W. E. 3rd, Loria, R. M., Ledney, G. D., & Seed, T. M. (2000). "Androstenediol stimulates myelopoiesis and enhances resistance to infection in gamma-irradiated mice". Int. J. Immunopharmacol. 22 (1): 1–14. doi:10.1016/s0192-0561(99)00059-4.