Anaplastic lymphoma kinase
Anaplastic lymphoma kinase gene is mapped on chromosome 2p23.2-p23.1 that encodes 1620 amino acids with a span of 180kDa which has been originally describe as a novel tyrosine phosphoprotein in anaplastic large cell lymphoma cell lines that mostly expressed in testis, intestine andbrain but absent in normal lymphoid cells. Its extracellular region consists of a unique combination of receptor tyrosine kinase exhibiting an N-terminal signal peptide with two meprin A5 protein domains.
Anaplastic lymphoma kinase plays a significant function in the development of the brain which exerts effects on specific neurons in the nervous system. It is implicated in oncogene when rearranged, amplified and mutated and which has been known in the development of some diseases like lymphomas, lung cancers and inflammatory myofibroblastic tumors yet recent evidence reveals that it is responsible for neuroblastoma, a brain cancer during childhood.
Anaplastic lymphoma kinase displays the classical structural features with anextracellular ligand-binding domain that belongs to the group of leukocyte tyrosine kinase. The domain organization of ALK is conserved throughout evolution of the kinase domains at about 87% overall homology, however in human ALK contains an extra four amino acids compare to other lower life forms, thus showing the utmost sequence similarity to the insulin receptor subfamily of kinases.
Gene name: ALK
Protein name: ALK tyrosine kinase receptor