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Anaplasma phagocytophilum

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A small intracellular obligate bacterium identified from the tick bites which infects and colonizes neutrophil granulocytes in the host organisms that leads to immunodeficiency disease.


Anaplasma phagocytophilum has 16S rRNA gene variants that cycle differently in the blood of infected host where some strain carries MSP4 by 23 amino acids. It is widely found in North America, Europe and Asia with 1264 protein genes containing no plasmids and with a length of 0.2-2 micrometer diameter that replicates within host cell vacuole to form a morula microcolony.

Anaplasma phagocytophilum involved in the host species and immunological condition of host that formed phagocytic cells identified to survive and replicate within neutrophil granulocytes associated by inflammatory responses modulated by several stimuli deployed by the tick components. It is mostly found to persist in sheep, cattle, horses, dog and red deer however it varies according to the variants of the bacterium involved.

Anaplasma phagocytophilum is implicated in anaplasmosis a tick-borne disease where group of small bacteria present in the blood neutrophils that manifest symptoms including headache, fever, leucopenia, thrombocytopenia and mild liver injury as well as caused lameness, ataxia and painful limbs.

Scientific classification:

Kingdom: Bacteria    
Phylum: Proteobacteria
Class: Alphaproteobacteria
Order: Rickettsiales
Family: Ehrlichiaceae
Genus: Anaplasma
Species: Anaplasma phagocytophilum 

See also:


Tick-borne disease

Obligate organisms