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5-hydroxyindole acetic acid

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5-hydroxyindole acetic acid

(Science: biochemistry tumour marker) this is a metabolite of serotonin that is excreted in the urine.

serotonin is a neurotransmitter that is synthesised from the amino acid tryptophan by enterochromaffin cells in the gut and bronchi. It is metabolised to 5-hydroxyindole acetic acid in the liver and then excreted in the urine.

elevations in 5-hydroxyindole acetic acid can indicate carcinoid tumour. The normal range in a 24 hour urine collection is 3 to 15 mg per 24 hours.

Acronym: 5-HIAA