Discussion of all aspects of biological molecules, biochemical processes and laboratory procedures in the field.
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- Posts: 36
- Joined: Sat Jan 27, 2007 8:32 pm
- Location: India
Why circular plasmid is preferred to linear plasmid?
- Posts: 157
- Joined: Sun Dec 03, 2006 8:03 pm
- Location: Israel, Haifa
I know two reasons:
- linear plasmide is sensitive to DNAase that must be within the cell
- circular plasmid have not problems with duplication - all known pherments can not duplicate end of nucleic acid. so, we need mechanis like telomerase.
Evolution will arrange everything
- Inland Taipan
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- Joined: Thu Mar 03, 2005 10:18 pm
- Location: Romania(small and unimportant country)
yes, linear plasmids would be chopped up by exonucleases within bacterial cells.
"As a biologist, I firmly believe that when you're dead, you're dead. Except for what you live behind in history. That's the only afterlife" - J. Craig Venter
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