Oxidation of amino acids

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DerHaus
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Oxidation of amino acids

Post by DerHaus » Sat Jan 06, 2007 6:37 pm

Hey

Could someone tell me the number of ATP produced by the oxidation of: leucine, phenylalanine, aspartic acid, cysteine, and glutamic acid?
i really donno how to do this, so if u dont mind could u sort of explain how u got the answer.

thanks

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Post by sdekivit » Sat Jan 06, 2007 7:44 pm

well catabolism of these amino acids will result in Krebs cycle intermediates. If you know these, you can calculate how many ATP is generated during this TCA-cycle coupled to oxidative phosphorylation.

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Post by mith » Sat Jan 06, 2007 7:49 pm

http://courses.cm.utexas.edu/archive/Sp ... /Lec22.htm

I think you can look at the corresponding pathways and determine it from there.
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Post by DerHaus » Sat Jan 06, 2007 11:17 pm

thanks for the website, i went through it.
well i know that leucine is converted into acetyl-CoA after its deamination. so what i think was that leucine should go straight to the kreb cycle without going through glycolysis. it makes 12 ATPs in Kreb cycle. so is that mean one leucine produces 12 ATPs in total?

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Post by MrMistery » Sun Jan 07, 2007 10:38 am

yes.....
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Answer of oxidation of amino acids

Post by Tan Tze Chein » Sat Jan 13, 2007 5:40 am

The oxidation of amino acids is depends of the number of carbon in the particular amino acids. The amino acids will convert into the intermediates in the TCA cycle to generate ATP molecules.

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Re: Answer of oxidation of amino acids

Post by sachin » Sat Jan 13, 2007 5:43 am

Tan Tze Chein wrote:The oxidation of amino acids is depends of the number of carbon in the particular amino acids. The amino acids will convert into the intermediates in the TCA cycle to generate ATP molecules.


Yes; thats right...... TCA pathway is same but intermediate conversion of amino acids to the initial substance of TCA is different for diff. a.a.
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Post by Tan Tze Chein » Sat Jan 13, 2007 10:42 am

I am sorry that I do not know how many carbon in all the amino acids, so I can not give you the answers on the ATP produced during the breakdown of the amino acids which you mentioned in the previous title.

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Post by sdekivit » Sat Jan 13, 2007 7:16 pm

DerHaus wrote:thanks for the website, i went through it.
well i know that leucine is converted into acetyl-CoA after its deamination. so what i think was that leucine should go straight to the kreb cycle without going through glycolysis. it makes 12 ATPs in Kreb cycle. so is that mean one leucine produces 12 ATPs in total?


depends on what you learned. I am told in lectures that 1 NADH yields 2,5 ATP and 1 FADH2 yields 1,5 ATP.

--> since the Krebs cycle yields 3 NADH, 1 FADH2 and 1 GTP, the amount of ATP generated in the Krebs cycle is (3 * 2,5) + 1,5 + 1 = 10 ATP

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Post by Dustfinger » Mon Jan 15, 2007 10:59 am

@Der Haus
Are you from Germany ? It' "Das Haus" rather ! :lol:
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Post by DerHaus » Thu Feb 01, 2007 12:30 am

im not from germany lol; i live in canada. i know a bit of german cuz im currently taking a german language course in school. obviously im not good at it lol. but o well...

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