Phosphorylation of Cdks

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medbio
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Phosphorylation of Cdks

Post by medbio » Sun Dec 10, 2006 1:50 am

I have a novel protein which is thought to be a substrate of the Cdk1 kinase. Can anyone tell me whats the benefit in knowing the specific site of phosphorylation??

Thanks, in advance! :)
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Enzyme
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Post by Enzyme » Sat Dec 23, 2006 7:34 pm

If you know the specific site of phosphorilation, your protein will inhibit the activity of the CDK1. This is a benefit when the cell has anormal replications (tumor cells) and it is necessary to stop the process. If the complex CDK1-cycline B is inhibit, the cell will stop its division in the G2/M transition (cyclines and CDKs promote positively the cell division).
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