Targets of Penicillin G and Vancomycin. Gram +ve or -ve?

About microscopic forms of life, including Bacteria, Archea, protozoans, algae and fungi. Topics relating to viruses, viroids and prions also belong here.

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Targets of Penicillin G and Vancomycin. Gram +ve or -ve?

Post by skyey_sky » Thu Dec 07, 2006 3:09 pm

I would like to know why is Gram-negative bacteria impermeable to penicillin G?

I know that vancomycin kills Gram-positive bacteria, but can it kill Gram-negative bacteria as well?And how? I think it is too large to enter the outer membrane of Gram-nagative bacteria.

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Post by mmiaosmiling » Sat Dec 09, 2006 10:41 am

penicillin G prevents the assembling of peptidoglycan so it can stop the reproducing.
G+ bacterium have much thicker cell walls than G- ones so most of them are more sensitive to penicillin.
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