enzymes

Discussion of all aspects of biological molecules, biochemical processes and laboratory procedures in the field.

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asdfgh
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enzymes

Post by asdfgh » Wed Nov 08, 2006 10:07 pm

why do some ezymes [ in the stomach such as pepsin] function at a low ph?

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Poison
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Post by Poison » Wed Nov 08, 2006 10:15 pm

Pepsinogen zymogen is activated by HCl and turns to active enzyme pepsin.
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Post by asdfgh » Wed Nov 08, 2006 10:20 pm

yea, dont really understand that..

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Poison
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Post by Poison » Wed Nov 08, 2006 10:23 pm

Do you know what is zymogen and acitve enzyme?
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honeev
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Post by honeev » Thu Nov 09, 2006 1:07 am

Some enzymes like pepsin are able to function at low pH generally because their structure are stable when pH is low. For instance when pepsin is exposed at higher pH (for example pH of 6.0) pepsin denaturation will occur but not at low pH (of about pH of 2.0). So this becomes the optimum pH for pepsin. Perhaps the reason behind this is because at low pH the amount of hydrogen ions are enough to keep the structure of pepsin fold properly. Thus this makes pepsin able to function properly at low pH.



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Last edited by honeev on Fri Nov 10, 2006 12:27 am, edited 2 times in total.
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Post by MrMistery » Thu Nov 09, 2006 6:53 pm

jees honee_v, write entire words! if i didn't know biology i couldn't have made heads or tails of what you said..
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Post by honeev » Thu Nov 09, 2006 11:24 pm

@MrMistery

ok i will
i only do that to sound cordial to everybody here...
i guess ive forgotten my motto... which is
when trying to please everybody ill end up pleasing noone...
thanks for reminding me..


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sachin
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Post by sachin » Fri Nov 10, 2006 4:42 pm

Can protein toxins such as "hemolysin-d" be digested at low pH, if it self it increases the pH of stomach on intake?
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Post by asdfgh » Mon Nov 13, 2006 10:48 pm

that helps me, thanks.

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