Respiration and Hydrogen cyanide

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dan167
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Respiration and Hydrogen cyanide

Post by dan167 » Mon Oct 30, 2006 7:48 pm

Can someone briefly explain how HCN inhibits respiration. I am particulary intrested to know if it stops the krebs cycle.
Thanks

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victor
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Post by victor » Tue Oct 31, 2006 6:47 am

I think NaCN is better than HCN for inhibiting respiration since NaCN will fully get dissociated into Na+ and CN- while HCN won't do that. So, the problem here is the CN- or cyanide ion. This ion inhibits the ETC for at the last electron accptor which is oxygen, but only for NADH pathway. So, we'll only earn 2/3 from the total ATP yield from NADH.

My professor said that this ATP yield reduction can be fatal for organisms, so that's why the cyanide poison can kills us fast...:lol:
Q: Why are chemists great for solving problems?
A: They have all the solutions.

dan167
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Post by dan167 » Tue Oct 31, 2006 9:04 pm

Thankyou :D but there is one part I dont understand. How come we will still get 1/3 of the NADH?

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