Ketone bodies

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biology_06er
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Ketone bodies

Post by biology_06er » Sat Oct 28, 2006 8:47 am

Hi

ok so ketone bodies used for fuel by brain in server starvation right?

Well ketone bodies are made by acetyl-CoA that have accumulated from FFA via B-oxidation...but then i go and look at the pathway of ketone bodies and it just ends up making acetyl-CoA all over again...SO whats the point in the ketone bodies being made in the first place?...sorry if this is such a dumb question but am a lil confused!!

Thanks
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sachin
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Post by sachin » Sat Oct 28, 2006 9:07 am

You refer WHole Kreb Cycle
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Post by biology_06er » Sat Oct 28, 2006 9:38 am

What?? I don't get it

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Post by sachin » Sat Oct 28, 2006 9:42 am

Refer the first part of Kreb cycle in details.

Where co-A is added to pyruvate.====>Acetyl co-A

may you get some hint there.
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Post by biology_06er » Sat Oct 28, 2006 9:59 am

hmm ok well yes it makes acetyl-CoA but that turns into citrate? I don't see any relevance....if brain uses ketone bodies in starved state I can understand that-thats why they are formed frm excess acetyl-CoA vis FA ox'dn. but why then is b-hydroxybutyrate converted back to acetoacetate>>actoacetyl-CoA>>>2*acetyl-CoA...I have no idea why this happens--cannot relate this make to TCA cycle and don't think i eva will be!!

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