which amino acid cannot form helical structure

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toxygen
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which amino acid cannot form helical structure

Post by toxygen » Tue Oct 24, 2006 3:46 pm

hello people ;)
can anyone help me with this please?

which proteinogenic amino acid is not able to form (ordinary) stable helical structure, while we suppose that the polypeptide chain of this stable helical structure must be made only by this amino acid.

:arrow: thanks in advance.

Ultrashogun
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Post by Ultrashogun » Tue Oct 24, 2006 7:17 pm

I think youre searching for Proline.

toxygen
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Post by toxygen » Thu Oct 26, 2006 6:52 am

can you please explain why?
despite the fact I read

Proline is the only proteinogenic amino acid whose side group cyclizes onto the backbone: it links to the α-amino group, and thus is also the only proteinogenic amino acid containing a secondary amine at this position. Proline has sometimes been termed an imino acid, but this is not correct by current nomenclature rules.


I don't understand clearly what's going on there.

oppox
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Post by oppox » Thu Oct 26, 2006 8:54 am

look at the structure of proline, it "forces" the chain into a bend that would break helical structure. Thus it can be found in turns/hairpins between helicals etc. Think of it like a u-turn :)

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Post by toxygen » Thu Oct 26, 2006 2:08 pm

thank you very much.

appreciated a lot. :D

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