Why is mucous so thick in cystic fibrosis patients?

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Jonathan488
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Why is mucous so thick in cystic fibrosis patients?

Post by Jonathan488 » Tue Oct 24, 2006 12:48 am

Why is mucous so thick in cystic fibrosis patients? Please help! I need an explanation on a cellular level. THANK YOU!

DMDhopefully
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Post by DMDhopefully » Tue Oct 24, 2006 1:03 am

The cells lining the airway in a person without cystic fibrosis allow Cl- atoms to leave the cells through pores into the mucus in the airway. The addition of Cl- prompts H20 and Na+ to enter the airway giving the mucus the correct consistancy (not sure if its a active pump for Na+ or leakage channels). Cystic Fibrosis blocks (or doesnt have not sure) pores to allow Cl- ions out of the cells lining the airway, which keeps water and sodium ions from "wanting" to enter the mucus in the airway. This dehydrates the mucus causing build up of bacteria. This is probably a watered down version but I dont have my book on me to reread it.

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